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If you drink alcohol regularly, talk with your doctor before changing the amount you drink. Wellbutrin can cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication.. Call your doctor at once if you have a seizure (convulsions) or fast, uneven heartbeats. You should not take Wellbutrin if you have epilepsy or a seizure disorder, an eating disorder such as anorexia or bulimia, if you are using a second form of bupropion, or if you have suddenly stopped using alcohol or sedatives. Do not take Wellbutrin if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl), or tranylcypromine (Parnate) in the last 14 days.. What other drugs will affect wellbutrin? Do not take Wellbutrin if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl), or tranylcypromine (Parnate) in the last 14 days. You should not take Wellbutrin if you have: epilepsy or a seizure disorder; wellbutrin withdrawals Do not take Wellbutrin if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl), or tranylcypromine (Parnate) in the last 14 days. You should not take Wellbutrin if you have: epilepsy or a seizure disorder; lamictal + wellbutrin Where can I get more information? wellbutrin effectiveness This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. anxiety and wellbutrin Do not smoke at any time if you are using a nicotine product along with Zyban. Too much nicotine can cause serious side effects. 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